Preparation method of aldehyde compound

ABSTRACT

A preparation method of an aldehyde compound of the present invention includes a step of reacting the compound represented by the following general formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound including 0.01 ppmmol to 10 ppmmol of a metal belonging to Groups 8 to 10 with respect to 1 mole of the compound and a phosphorus compound, and the amount of a chlorine portion in the reaction system in the step is equal to or less than 1.5 parts by weight with respect to 1 part by weight of the metal belonging to Groups 8 to 10.

TECHNICAL FIELD

The present invention relates to a preparation method of an aldehyde compound, a preparation method of an amine compound and a preparation method of an isocyanate compound using the aldehyde compound obtained by the preparation method.

BACKGROUND ART

As a manufacturing method of an aldehyde compound using norbornene compound, for example, methods described in Patent Documents 1 to 3 are known.

Patent Documents 1 to 3 disclose methods for manufacturing formyl cyan norbornene by hydroformylating cyan norbornene using a mixed H₂/CO gas in the presence of a catalyst. Patent Documents 1 and 2 disclose an example using a metal compound as a catalyst. Moreover, since it is possible to obtain a target compound with high selectivity, and it is possible to suppress the reaction pressure to be low, a rhodium complex is preferably used as the catalyst.

Patent Document 1 describes that the catalyst may be used at 0.1% by weight to 10% by weight with respect to cyan norbornene. Patent Document 2 describes that with the catalyst concentration of 0.5 mmol/1 to 10 mmol/l, triarylphosphine can be used in a range of 3 moles to 300 moles with respect to 1 mole of rhodium.

Patent Document 4 discloses a method of hydroformylating an olefin-based compound using a mixed H₂/CO gas in the presence of a transition metal catalyst and a trivalent phosphorus compound. Furthermore, it is described that as the content of the metal catalyst, a free metal content is 10 ppm to 1,000 ppm based on the weight or volume of the catalyst composition.

Patent Document 5 describes a metal ligand complex catalyst, and exemplifies rhodium as a metal and an organic phosphorus ligand as a ligand. In addition, it is described that the amount of these used, in a case of calculating as a free metal, is a metal concentration in a range of about 1 ppm to 10,000 ppm, and a molar ratio of ligand:metal is 1:1 to 200:1.

In addition, Patent Documents 6 and 7 disclose a method of preparing an aldehyde compound by hydroformylating a linear olefin compound.

In Examples of Patent Document 6, an example of hydroformylating 7-octenal in the presence of a rhodium catalyst and bisphosphite is described. In addition, it is described that about 3 ppmmol, rhodium is used with respect to 1 mole of 7-octenal, and rhodium atoms/phosphorus atoms is 1/20 as a molar ratio. On the other hand, in paragraph 0084 of Patent Document 6, it is described that 2 moles to 1,000 moles in terms of phosphorus atom is preferable with respect to 1 mole of a metal, and in a case of exceeding 1,000 moles, the reaction rate tends to be extremely low.

In addition, Patent Document 7 describes that in the hydroformylation of the olefin, materials such as a halogenated organic compounds are required to be excluded from the reaction, however there is no description regarding the amounts.

RELATED DOCUMENT Patent Document

[Patent Document 1] Japanese Laid-open Patent Publication No. 57-193438

[Patent Document 2] Japanese Laid-open Patent Publication No. 60-72844

[Patent Document 3] U.S. Pat. No. 3,143,570

[Patent Document 4] Japanese Translation of PCT International Application No. 2010-538818

[Patent Document 5] Japanese Translation of PCT International Application No. 2003-505438

[Patent Document 6] Japanese Laid-open Patent Publication No. 2008-031125

[Patent Document 7] Japanese Translation of PCT International Application No. 4-502463

DISCLOSURE OF THE INVENTION

In recent years, the amount of rare metal used has increased with the development of technology, and depletion of rare metal resources and price rises have become a problem. Therefore, reducing the amount of so-called rare metals used and effective use thereof have been widely sought.

However, it is found that in the hydroformylation reaction of a norbornene compound, for example, cyanonorbornene, when reducing the amount of a metal compound which is a catalyst, a problem in productivity such as decrease in the reaction rate or decrease in the yield due to stopping of the reaction itself occurs. In industrial production, decrease in the reaction rate causes a problem in connection to the next step, and thus, production cannot be efficiently performed.

The present invention has been made in consideration of the above problems, and an object of the present invention is to provide an industrially advantageous method in which the amount of a metal which is an expensive catalyst is reduced, and which can suppress decrease in the reaction rate even in a case where the amount of the metal is reduced when aldehyde is prepared.

As a result of thorough studies of factors decreasing the reaction rate in order to solve the above problems, the present inventor found that when a chlorine portion is present in the reaction system, the reaction rate is decreased. As a result of further studies, the inventor found that it is possible to prepare aldehyde without reducing the reaction rate by controlling the amount of chlorine atoms in the reaction system, and made the present invention.

The present invention can be described as follows.

[1] A preparation method of aldehyde compound including a step of reacting a compound represented by the following general formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound including 0.01 ppmmol to 10 ppmmol of a metal belonging to Groups 8 to 10 with respect to 1 mole of the compound and a phosphorus compound, in which the amount of a chlorine portion in the reaction system in the step is equal to or less than 1.5 parts by weight with respect to 1 part by weight of the metal belonging to Groups 8 to 10.

(In the formula (a1), X represents a hydrogen atom, a cyano group, an aldehyde group, or a —CH═NR group, and R represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an aryl group. In the formulas (a1) and (a2), n represents 0, 1 or 2.)

[2] The preparation method of an aldehyde compound according to [1], in which the metal compound including a metal belonging to Groups 8 to 10 is a rhodium compound, a cobalt compound, a ruthenium compound, or an iron compound.

[3] The preparation method of an aldehyde compound according to [1] or [2], in which the metal compound including the metal belonging to Groups 8 to 10 is a rhodium compound.

[4] The preparation method of an aldehyde compound according to any one of [1] to [3], in which the amount of the metal belonging to Groups 8 to 10 is 1 ppmmol to 5 ppmmol with respect to 1 mole of the compound represented by the general formula (a1) or (a2).

[5] The preparation method of an aldehyde compound according to any one of [1] to [4], in which the phosphorus compound is a trivalent phosphorus compound.

[6] The preparation method of an aldehyde compound according to any one of [1] to [5], in which the compound represented by the general formula (a1) is used, and the compound is the compound represented by the following formula (1).

(In the formula (1), X is the same as that in the general formula (a1).)

[7] A preparation method of an amine compound including a step of reacting the aldehyde compound obtained by the preparation method according to any one of [1] to [6] with ammonia, and hydrogen in the presence of a catalyst.

[8] A preparation method of an isocyanate compound including a step of reacting the amine compound obtained by the preparation method according to [7] with a carbonylating agent.

Moreover, the “phosphorous compound” in the present invention means a phosphorous compound capable of forming a complex with a metal.

In addition, in the present invention, in a case where a material B is used in the amount of 1×10⁻⁶ moles with respect to 1 mole of a material A, the amount of the material B is indicated as 1 ppmmol.

According to the preparation method of an aldehyde compound of the present invention, even in a case where the amount of metal which is a catalyst is reduced, a decrease in the reaction rate is suppressed, and industrially advantageous preparation of aldehyde can be achieved. Since the preparation method of an amine compound and the preparation method of an isocyanate compound of the present invention include the preparation method of an aldehyde compound as one step, according to the present invention, the effect is exhibited that productivity and yield of the isocyanate compound and the amine compound also are excellent.

BRIEF DESCRIPTION OF THE DRAWINGS

The above-described objects, other objects, features, and advantages will be made clearer from the preferred embodiments described below, and the following accompanying drawings.

FIG. 1 is a ¹H-NMR chart of the compound obtained in Example 1.

FIG. 2 is a ¹H-NMR chart of the compound obtained in Example 2.

FIG. 3 is a ¹H-NMR chart of the compound obtained in Example 3.

DESCRIPTION OF EMBODIMENTS

Hereinafter, the preparation method of an aldehyde compound of the present embodiment will be described, and the preparation method of an amine compound, and then, the preparation method of an isocyanate compound will be described.

Preparation Method of Aldehyde Compound

The preparation method of an aldehyde compound of the present embodiment includes a step of reacting the compound represented by the following general formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound including a metal belonging to Groups 8 to 10 and a phosphorus compound, and the amount of chlorine atoms in the reaction system in the step is equal to or less than 1.5 parts by weight with respect to 1 part by weight of the metal belonging to Groups 8 to 10.

In the formula (a1), X represents a hydrogen atom, a cyano group, an aldehyde group, or a —CH═NR group, and R represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an aryl group having 6 to 20 carbon atoms. As X, a cyano group or an aldehyde group is preferable, and a cyano group is more preferable. In the formulas (a1) and (a2), n represents 0, 1, or 2, and 0 or 1 is preferable, and 1 is more preferable.

Moreover, the compound represented by the general formula (a1) may be an endo compound or an exo compound, and may be a mixture including these in arbitrary proportions.

As the compound represented by the general formula (a1), specifically, the following compounds can be exemplified.

(1) As the compound having 0 as n, cyclohexene, 4-cyano-1-cyclohexene, 3-cyclohexene-1-carboxyaldehyde, and 4-iminomethyl-1-cyclohexene can be exemplified.

(2) As the compound having 1 as n, bicyclo[2.2.1]-2-heptene, bicyclo[2.2.1]-5-heptene-2-carbonitrile, bicyclo[2.2.1]-5-heptene-2-carboxyaldehyde, and bicyclo[2.2.1]-5-hepten-2-yl methaneamine can be exemplified.

(3) As the compound having 2 as n, bicyclo[2.2.2]-2-octene, bicyclo[2.2.2]-5-octene-2-carbonitrile, bicyclo[2.2.2]-5-octene-2-carboxyaldehyde, and bicyclo[2.2.2]-5-hepten-2-yl methaneamine can be exemplified.

As the compound represented by the general formula (a2), the following compounds can be exemplified.

(1) As the compound having 0 as n, 1,4-cyclohexadiene can be exemplified.

(2) As the compound having 1 as n, bicyclo[2.2.1]hepta-2,5-diene can be exemplified.

(3) As the compound having 2 as n, bicyclo[2.2.2]octa-2,5-diene can be exemplified.

In the present embodiment, the compound represented by the general formula (a1) is preferably used, and n is more preferably 1. As the compound, specifically, the compound represented by the following general formula (1) can be preferably used.

In the formula (1), X is the same as that in the general formula (a1), and a cyano group or an aldehyde group is preferable, and a cyano group is more preferable.

Moreover, the compound represented by the general formula (1) may be an endo compound or an exo compound, and may be a mixture including these in arbitrary proportions.

The metal compound including a metal belonging to Groups 8 to 10 used in the reaction of the present embodiment is a rhodium compound, a cobalt compound, a ruthenium compound, or an iron compound.

Examples of the rhodium compound include Rh(acac)(CO)₂, Rh(acac)₃, Rhe₂(CO)₈, Rh₄(CO)₁₂, and Rh₆(CO)₁₆. Examples of the cobalt compound include HCo(CO)₃, HCo(CO)₄, CO₂(CO)₈, and HCo₃(CO)₉. Examples of the ruthenium compound include Ru(CO)₃(PPh₃)₂ and Ru₃(CO)₁₂. In addition, examples of the iron compound include Fe(CO)₅, Fe(CO)₄PPh₃, and Fe(CO)₄(PPh₃)₂. Moreover, “acac” means acetylacetonato.

The rhodium compound used in the reaction of the present embodiment is not particularly limited as long as it is a compound including monovalent rhodium metal, and rhodium carbonyl catalysts such as dicarbonylacetylacetonato rhodium (Rh(acac) (CO)₂), dodecacarbonyl tetrarhodium (Rh₄(CO)₁₂), hexadecacarbonyl hexarhodium (Rh₆(CO)₁₆), and octacarbonyl dirhodium (Rh₂(CO)₈) can be exemplified.

The phosphorus compound used in the reaction of the present embodiment is not particularly limited as long as it is a trivalent phosphorus compound, and the compound represented by the following formula is preferably used.

(R¹)₃P

(R²O)₃P

In the above formula, R¹ and R² may be the same as or different from each other, and each of R¹ and R² represents an alkyl group having 1 to 16 carbon atoms or an aryl group having 6 to 16 carbon atoms which may have a substituent.

As the phosphorus compound, specifically, trivalent phosphorus compounds such as triphenyl phosphite, triphenyl phosphine, trimethyl phosphine, triethyl phosphine, tripropyl phosphine, tri(methyl benzene)phosphine, tri(ethyl benzene)phosphine, 1,2-bis(diphenyl phosphino)ethylene, 1,3-bis(diphenyl phosphino)propane, 2,2-bis(diphenyl phosphino)-1,1-binaphthyl, trimethoxy phosphite, triethoxy phosphite, tripropoxy phosphite, triisopropoxy phosphite, trimethylphenyl phosphite, and tris(2,4-di-tert-butylphenyl)phosphite can be exemplified. In the present embodiment, triphenyl phosphite is preferably used.

In general, these compounds are synthesized by a reaction of phosphorus trichloride or phosphorus pentachloride with an aromatic compound, an alicyclic compound, or an aliphatic compound which may include a substituent. Accordingly, a chlorine portion such as phosphorus trichloride or phosphorus pentachloride which is a raw material, a chlorine portion such as hydrogen chloride or chlorine which is a by-product, or a chlorine-containing intermediate generated as a by-product in the reaction are mixed into the phosphorus compound. Although it is considered that chlorine atoms present in the reaction system are derived from the phosphorus compound, chlorine portion included in other raw materials or the like may also be contained therein.

Moreover, in a case where the metal compound including a metal belonging to Groups 8 to 10 does not include a chlorine atom in the structure, and chlorine-containing compounds are not used in the synthesis step as raw materials other than the phosphorus compound, it is therefore considered that chlorine atoms in the reaction system are derived from the phosphorus compound. That is, in this case, chlorine atoms of the amount described below are included in the phosphorus compound with respect to 1 part by weight of the metal belonging to Groups 8 to 10.

In a case where the amount of the chlorine portion included in the phosphorus compound becomes the above predetermined amount, it is not necessary to reduce the chlorine portion of the phosphorus compound, however, in a case where the amount of the chlorine portion is greater than the above predetermined amount such as a case where the metal compound including a metal belonging to Groups 8 to 10 includes a chlorine atom in the structure, it is possible to reduce the amount of chlorine portion included in the phosphorus compound by a method such as Lopping or an activated carbon treatment. Moreover, the method for reducing the amount of chlorine portion is not limited to these.

In the hydroformylation reaction using these raw materials, the amount of metal belonging to Groups 8 to 10 to be used is 0.01 ppmmol to 10 ppmmol, and preferably 1 ppmmol to 10 ppmmol, and more preferably 1 ppmmol to 5 ppmmol with respect to 1 mole of the compound represented by the formula (a1) or (a2). When the amount is in the above numerical range, it is possible to ensure smooth progress of the reaction without excessively using an expensive catalyst.

In addition, the amount of phosphorus compound used is preferably equal to or greater than 100-fold by mole, more preferably 100-fold by mole to 10,000-fold by mole with respect to the metal belonging to Groups 8 to 10. Moreover, the above numerical range can be combined arbitrarily.

The amount of chlorine atoms in the reaction system is equal to or less than 1.5 parts by weight, and preferably equal to or less than 1.2 parts by weight with respect to 1.0 part by weight of the metal belonging to Groups 8 to 10 from the viewpoint of the effect of the present invention. Moreover, although the lower limit value is not particularly limited, the lower limit value is equal to or greater than 0.1 parts by weight, and preferably equal to or greater than 0.5 parts by weight with respect to 1.0 part by weight of the metal belonging to Groups 8 to 10. When the amount is the lower limit value, the step of reducing the chlorine portion is simple and does not influence productivity, and thus, it is preferable. Moreover, the upper limit value and the lower limit value can be suitably combined.

Synthesis of the aldehyde compound, specifically, can be performed in the following manner.

First, a rhodium compound, a phosphorus compound, and a compound represented by the general formula (a1) or (a2) which is a raw material are put in a reactor. While supplying hydrogen and a carbon monoxide gas thereto, the mixture is allowed to react at a temperature of 30° C. to 120° C. and a pressure of 0.1 MPa to 1.0 MPa for 1 hour to 8 hours. Moreover, the hydroformylation reaction can be performed by suitably selecting a homogeneous reaction system configured of only an oil phase or a two-layer reaction system configured of a water layer and an oil layer.

Thus, the compound represented by the general formula (a1) or (a2) is hydrotormylated, whereby an aldehyde compound is synthesized.

Moreover, the hydroformylation reaction can also be performed without a solvent, or can be performed using a substituted or unsubstituted aromatic compound, a substituted or unsubstituted aliphatic hydrocarbon compound, or alcohol, and for example, the hydroformylation reaction can also be performed in a solvent such as toluene, benzene, hexane, octane, acetonitrile, benzonitrile, ethanol, pentanol, or octanol. The hydroformylation reaction in the present embodiment is also excellent in reactivity at a high concentration, and thus, the hydroformylation reaction can be performed without a solvent. As a result, since a step of distilling off a solvent or the like is not required, the step becomes simple, the volume efficiency also is improved, and the production efficiency also is excellent.

The aldehyde compound represented by the following general formula (b1) is synthesized from the compound of the general formula (a1) by the preparation method of the present embodiment. The aldehyde compound represented by the following general formula (b2) is synthesized from the compound of the general formula (a2).

In a case where n is 1 or 2 and X is a group other than a hydrogen atom, the compound represented by the general formula (b1) or (b2) can be obtained as any one of “a compound in which the 2-position and the 5-position are substituted with predetermined groups (hereinafter, referred to as a 2,5-isomer)” and “a compound in which the 2-position and the 6-position are substituted with predetermined groups (hereinafter, referred to as a 2,6-isomer)”, or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions.

Moreover, in a case where n is 0 and X is a group other than a hydrogen atom, the compound represented by the general formula (b1) or (b2) can be obtained as any one of a cis-type and a trans-type, or can also be obtained as a mixture including these in arbitrary proportions.

In the general formula (b1) or (b2), X and n are the same as those in the general formula (a1) or (a2).

In the present embodiment, the compound represented by the general formula (b1) is preferably obtained, and as the compound, the compound represented by the following general formula (2) can be exemplified.

In the formula (2), X is the same as that in the general formula (1)

Moreover, the aldehyde compound represented by the general formula (2) can be obtained as any one of “a compound in which the 2-position of bicyclo[2.2.1]heptane is substituted with a substituent X and the 5-position is substituted with an aldehyde group (hereinafter, referred to as a 2,5-isomer)” and “a compound in which the 2-position is substituted with a substituent X and the 6-position is substituted with an aldehyde group (hereinafter, referred to as a 2,6-isomer)”, or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions.

After the hydroformylation reaction is finished, a target aldehyde compound can be obtained by performing a predetermined purification step.

Preparation Method of Amine Compound

The preparation method of an amine compound of the present embodiment includes the following steps.

Step (a): In the presence of a metal compound including a metal belonging to Groups 8 to 10 and a phosphorus compound, the compound represented by the general formula (a1) or (a2) is reacted with hydrogen and carbon monoxide.

Step (b): The aldehyde compound obtained in the step (a) is reacted with ammonia, and reacted with hydrogen in the presence of a catalyst.

The preparation method of an amine compound of the present embodiment includes the preparation method of an aldehyde compound described above as the step (a). Therefore, the productivity and yield of the aldehyde compound are excellent in the step (a), and thus, the productivity and yield of the amine compound which is a target compound are also excellent.

Moreover, since the step (a) is the same as the step in the above-described “the preparation method of an aldehyde compound”, the description thereof will not be repeated.

In the step (b), by performing imination by reacting the aldehyde compound obtained in the step (a) and represented by the general formula (b1) or the following general formula (b2) with ammonia and hydrogenation in the presence of a catalyst, an amine compound is synthesized.

As the catalyst, metal catalysts such as nickel, platinum, palladium, and ruthenium can be used. In a case where the aldehyde compound has a cyano group as a substituent, a —CH₂—NH₂ group is produced by hydrogen reduction.

In this manner, in the step (b), the aldehyde group of the aldehyde compound becomes an amino group by amination, and the cyano group also becomes an amino group by hydrogen reduction, and thus, the amine compound represented by the following general formula (c1) having two amino groups is synthesized. Moreover, in a case where X is a hydrogen atom, the amine compound represented by the following general formula (c2) is synthesized.

In the formula (c1) or (c2), n is the same as that in the general formula (a1) or (a2).

In a case where n is 1 or 2, the compound represented by the general formula (c1) can be obtained as any one of “a compound in which the 2-position and the 5-position are substituted with predetermined groups (hereinafter, referred to as a 2,5-isomer)” and “a compound in which the 2-position and the 6-position are substituted with predetermined groups (hereinafter, referred to as a 2,6-isomer)”, or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions.

Moreover, in a case where n is 0, the compound represented by the general formula (c1) can be obtained as any one of a cis-type and a trans-type, or can also be obtained as a mixture including these in arbitrary proportions.

In a case where n is 1 or 2, the compound represented by the general formula (c2) can be obtained as an endo compound or an exo compound, or can also be obtained as a mixture including these in arbitrary proportions.

In the present embodiment, the compound represented by the general formula (c1) is preferably obtained, and as the compound, the compound represented by the following chemical formula (3) in which n is 1 can be exemplified.

Moreover, the amine compound represented by the chemical formula (3) can be obtained as any one of “a compound in which the 2-position and the 5-position of bicyclo[2.2.1]heptane are substituted with aminomethyl groups (hereinafter, referred to as a 2,5-isomer)” and “a compound in which the 2-position and the 6-position are substituted with aminomethyl groups (hereinafter, referred to as a 2,6-isomer)”, or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions.

The above amination and hydrogenation reaction, specifically, can be performed in the following manner. First, an aldehyde compound, a solvent, and a catalyst are introduced into a reactor, and an ammonia gas is blown thereinto. Furthermore, hydrogen is injected at a pressure until the pressure in the reactor becomes about 1 MPa, then, the temperature is raised to about 100° C., and the reaction is allowed to proceed for about 1 hour to 10 hours at this temperature and pressure while supplying hydrogen. As the solvent, for example, an alcohol having 1 to 8 carbon atoms or water is preferably used.

Furthermore, after the reaction is finished, general catalyst filtration, desolventizing, and a purification step are performed, whereby a target amine compound can be obtained.

Preparation Method of Isocyanate Compound

The preparation method of an isocyanate compound of the present embodiment includes the following steps.

Step (a): In the presence of a metal compound including a metal belonging to Groups 8 to 10 and a phosphorus compound, the compound represented by the general formula (a1) or (a2) is reacted with hydrogen and carbon monoxide.

Step (b): The aldehyde compound obtained in the step (a) is reacted with ammonia, and reacted with hydrogen in the presence of a catalyst.

Step (c): The amine compound obtained in the step (b) is reacted with a carbonylating agent.

The preparation method of an isocyanate compound of the present embodiment includes the preparation method of an aldehyde compound described above as the step (a). Therefore, the productivity and yield of the aldehyde compound are excellent in the step (a), and thus, the productivity and yield of the isocyanate compound which is a target compound also are excellent.

Moreover, since the step (a) is the same as the step in the above-described “the preparation method of an aldehyde compound”, and the step (b) is the same as the step in the above-described “the preparation method of an amine compound”, the description thereof will not be repeated.

In the step (c), by reacting the amine compound obtained in the step (b) represented by the general formula (c1) or (c2) with a carbonylating agent under predetermined conditions, an isocyanate compound represented by the following general formula (d1) or (d2) is synthesized. As the carbonylating agent, phosgene, urea derivatives, carbonate derivatives, or carbon monoxide can be used.

In the formula (d1) or (d2), n is the same as that in the general formula (a1) or (a2).

In a case where n is 1 or 2, the compound represented by the general formula (d1) can be obtained as any one of “a compound in which the 2-position and the 5-position are substituted with predetermined groups (hereinafter, referred to as a 2,5-isomer)” and “a compound in which the 2-position and the 6-position are substituted with predetermined groups (hereinafter, referred to as a 2,6-isomer)”, or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions.

Moreover, in a case where n is 0, the compound represented by the general formula (d1) can be obtained as any one of a cis-type and a trans-type, or can also be obtained as a mixture including these in arbitrary proportions.

In a case where n is 1 or 2, the compound represented by the general formula (d2) can be obtained as an endo compound or an exo compound, or can also be obtained as a mixture including these in arbitrary proportions.

In the present embodiment, the compound represented by the general formula (d1) is preferably obtained, and as the compound, the compound represented by the following chemical formula (4) in which n is 1 can be exemplified.

Moreover, the isocyanate compound represented by the chemical formula (4) can be obtained as any one of “a compound in which the 2-position and the 5-position of bicyclo[2.2.1]heptane are substituted with isocyanatomethyl groups (hereinafter, referred to as a 2,5-isomer)” and “a compound in which the 2-position and the 6-position are substituted with isocyanatomethyl groups (hereinafter, referred to as a 2,6-isomer)”, or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions.

In a case of using phosgene as a carbonylating agent, as the step (c), specifically, a method in which first, an amine compound and a solvent are introduced into a reactor, then, the mixture is subjected to a hydrochlorination reaction using hydrochloric acid then, and reacted with phosgene or a method in which a carbamoyl chloride compound is obtained by directly reacting with phosgene, and the obtained carbamoyl chloride compound is subjected to a thermal decomposition can be exemplified. Furthermore, after the reaction is finished, a general purification step is performed, whereby a target isocyanate compound can be obtained.

Moreover, although the reaction solvent in a case of using phosgene as a carbonylating agent is not particularly limited, an organic aromatic compound having a high boiling point or an ester compound in which hydrochloric acid has a high solubility at the time of a salt formation reaction, and phosgene has a high solubility and hydrochloric acid has a low solubility at the time of a phosgenation reaction are preferably used. Examples of the organic aromatic compound having a high boiling point include 1,2-diethylbenzene, 1,3-diethylbenzene, 1,4-diethylbenzene, isopropylbenzene, 1,2,4-trimethylbenzene, amylbenzene, diamylbenzene, triamylbenzene, dodecylbenzene, p-cymene, cumene methylphenyl ether, ethylphenyl ether, diisoamyl ether, n-hexyl ether, ortho-dichlorobenzene, para-chlorotoluene, bromobenzene, and 1,2,4-trichlorobenzene. In addition, although the ester compound is not particularly limited, acetic esters such as isoamyl acetate and isooctyl acetate are preferable. Among these exemplified solvents, a particularly preferred solvent for performing the present invention is an aromatic halogen compound.

The isocyanate compound obtained by the present embodiment can be used as a raw material of optical materials or paint. Moreover, the amine compound obtained by the present embodiment can be used as paint or a raw material for a curing agent.

EXAMPLES

Hereinafter, the present invention will be further described in more detail with Examples, but the scope of the present invention is not limited to Examples.

Reference Example Synthesis of bicyclo[2.2.1]-5-heptene-2-carbonitrile

195.0 g (1.40 mol) of dicyclopentadiene having a purity of 95% and 163.6 g (3.08 mol) of acrylonitrile in which 0.36 g (1.8 mmol) of N-nitrosodiphenylamine was added were introduced into a 1,000 mL autoclave, then, the mixture was allowed to react at 160° C. for 5 hours with stirring, and after the temperature was raised to 180° C. and the resultant product was allowed to react for 2 hours, the reaction was finished. 355.6 g of reaction liquid including bicyclo[2.2.1]-5-heptene-2-carbonitrile was obtained, and when analysis of the reaction liquid was performed, 331.2 g (2.78 mol) of bicyclo[2.2.1]-5-heptene-2-carbonitrile was found to be contained therein. 352.4 g of the obtained reaction liquid including 328.2 g (2.75 mol) of bicyclo[2.2.1]-5-heptene-2-carbonitrile was introduced into a 500 mL flask, and distillation was performed under a reduced pressure, whereby 300.7 g (2.52 mol) of bicyclo[2.2.1]-5-heptene-2-carbonitrile was obtained as a main fraction.

Example 1 Synthesis of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane

50.0 mg (0.194 mmol) of rhodium acetylacetonate dicarbonyl and 16.0 g (0.133 mol) of bicyclo[2.2.1]-5-heptene-2-carbonitrile obtained in Reference Example, and 1.2 g (3.87 mmol) of triphenyl phosphite were introduced into a glass container having an internal volume of 0.1 L, then, the mixture was stirred at 25° C., and a catalyst master liquid was adjusted. Then, 0.81 g (0.926 mg in terms of Rh) of the catalyst master liquid and 214.8 g (1.8 mol) of bicyclo[2.2.1]-5-heptene-2-carbonitrile obtained in Reference Example, and 5.656 g (18.23 mmol) of triphenyl phosphite were introduced into an electromagnetic stirring type autoclave made of SUS316 L having an internal volume of 0.5 L, and the mixture was stirred at 25° C., whereby 221.3 g of a Rh catalyst adjusting liquid was obtained. When the chlorine portion in the triphenyl phosphite used at this time was measured by the following analytical method, the result was 110 ppm (0.622 mg). The amount was 0.7 parts by weight with respect to 1 part by weight of rhodium.

Amount of rhodium used: 5 ppmmol with respect to 1 mole of bicyclo[2.2.1]-5-heptene-2-carbonitrile

Quantitative Analysis Method of Chlorine Portion in Triphenyl Phosphite

The chlorine portion (amount of chlorine atom) in the tri phenyl phosphite was quantified by a coulometric titration method. This coulometric titration method is a method in which a sample is subjected to oxidative combustion using oxygen gas in an argon gas stream, due to this, chlorine compounds are converted to hydrogen chloride, and then, quantitative argentometry is performed on the produced hydrogen chloride.

The measurement instruments were as follows.

Autosampler apparatus: ASC-250 L

Horizontal type electric furnace: HF-210

Coulometer: MDC-210

Mitsubishi Chemical gas injector: GI-100

Auto boat controller: ABC-210

Then, after sufficiently replacing with nitrogen, replacement by a mixed gas having a volume ratio of carbon monoxide/hydrogen of 50/50 was sufficiently performed. The same gas was injected at pressure until the pressure in the autoclave became 0.6 MPaG, and under stirring, the temperature was raised to 80° C., whereby a hydroformylation reaction was started. Since the pressure in the autoclave was reduced with the progress of the reaction, the mixed gas was continuously supplied such that the pressure was maintained at 0. 6 MPaG, the liquid temperature was adjusted so as to be maintained at 80° C., and the time taken for the mixed gas having a volume ratio of carbon monoxide/hydrogen of 50/50 to reach 50% absorption of the theoretical amount was 1.5 hours. The reaction took 5 hours to complete, and the mixed gas in the system was purged with nitrogen, whereby 275.0 g of a reaction liquid including 2-cyano-5, (6)-formyl bicyclo[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed, 257.8 g (1.73 mol) of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was found to be contained therein. The reaction yield was 96.0 mol %.

The results are shown in Table 1.

263.8 g of a reaction liquid including 255.1 g (1.71 mol) of 2-cyano-5,(6)-formyl bicyclo[2.2.1]heptane, 4.7 g (0.02 mol) of triphenyl phosphite, and 14.0 g of water were introduced into a four-neck reaction flask having an internal volume of 2 L equipped with d reflux condenser, a stirring blade, and a thermometer, and after stirring the mixture, the temperature was raised to 80° C., and hydrolysis was performed for 2 hours. When analysis of the obtained solution was performed, 252.1 g (1.69 mol) of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was found to be contained therein, and triphenyl phosphite was not detected.

6.4 g (0.012 mol) of 20% by weight aqueous potassium hydrogencarbonate solution of was added dropwise to the hydrolyzed solution so as to give pH of 7.0 at 25° C.

Then, distillation was performed under a reduced pressure, whereby 264 g of a solution including 250.6 g (1.68 mol) of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. The solution was purified by distillation under a reduced pressure, whereby 244.7 g (1.64 mol) of a mixture of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. The ¹H-NMR chart of the mixture is shown in FIG. 1.

Example 2 Synthesis of 2,5-bisaminomethyl-bicyclo[2.2.1]heptane and 2,6-bisaminomethyl-bicyclo[2.2.1]heptane

89.5 g (0.6 mol) of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane obtained in Example 1, 89.5 g of methanol, and 4.5 g (dried mass) of a Raney cobalt catalyst (94% by mass of cobalt, 3.5% by mass of aluminum, and 2.1% by mass of manganese) obtained by developing a cobalt-aluminum alloy containing manganese were put into an electromagnetic stirring type autoclave made of stainless steel having an internal volume of 0.5 L, and 24.5 g (1.44 mol) of an ammonia gas was blown thereinto.

Then, after sufficiently replacing with nitrogen, replacement with hydrogen was performed. Furthermore, hydrogen was injected at pressure until the pressure in the autoclave became 1.2 MPaG, and under stirring, the temperature was raised to 100° C., whereby a reaction was started. Since the pressure in the autoclave was reduced with the progress of the reaction, hydrogen was continuously supplied such that the pressure was maintained at 1.2 MPaG, the liquid temperature was adjusted so as to be maintained at 100° C., and a hydrogenation reaction was performed for 6 hours.

After cooling the resultant product to room temperature, the Raney cobalt catalyst was removed by filtration, and ammonia and methanol were distilled off at 4 kPa and 60° C., whereby 102.0 g of a solution including 2,5-bisaminomethyl-bicyclo[2.2.1]heptane and 2,6-bisaminomethyl-bicyclo[2.2.1]heptane was obtained.

102.0 g of the obtained solution including 2,5-bisaminomethyl-bicyclo[2.2.1]heptane and 2,6-bisaminomethyl-bicyclo[2.2.1]heptane was introduced into a 200 mL flask, and distillation was performed under a reduced pressure, whereby 79.0 g of a purified mixture of 2,5-bisaminomethyl-bicyclo[2.2.1]heptane and 2,6-bisaminomethyl-bicyclo[2.2.1]heptane was obtained. The ¹H-NMR chart of the mixture is shown in FIG. 2. The same operation was repeated two times, whereby 158 g of a purified mixture of 2,5-bisaminomethyl-bicyclo[2.2.1]heptane and 2,6-bisaminomethyl-bicyclo[2.2.1]heptane was obtained.

Example 3 Synthesis of 2,5-bisisocyanatomethyl-bicyclo[2.2.1]heptane and 2,6-bisisocyanatomethyl-bicyclo[2.2.1]heptane

958 g of orthodichlorobenzene was introduced into a five-neck reaction flask having an internal volume of 2 L equipped with a reflux condenser, a stirring blade, a thermometer, a gas blowing tube, and a raw material introducing tube, and 154.2 g (1.0 mol) of 2,5-bisaminomethyl-bicyclo[2.2.1]heptane and 2,6-bisaminomethyl-bicyclo[2.2.1]heptane obtained in Example 2 and 702 g of orthodichlorobenzene were put into a raw material tank. Then, after raising the temperature of a reaction vessel to 120° C. at 0.1 MPa, introductions of hydrochloric acid gas at a rate of 43.8 g/hr from a hydrochloric acid blowing tube and an amine diluted with a solvent at a rate of 428.1 g/hr from the raw material tank through the raw material introducing pump into the reaction vessel were started at the same time, and the entire amount was introduced over 2 hours. Furthermore, aging was performed for 1 hour while introducing a hydrochloric acid gas at 20 g/hr. After the reaction was finished, the temperature of a hydrochloride reaction mass was raised to 160° C., then, phosgene was blown in at 100 g/hr (1.0 mol/hr) from a phosgene blowing tube, and the reaction was allowed to proceed for 6 hours while the temperature was maintained. After the reaction was finished, the unreacted phosgene and hydrochloric acid gas in the system were purged with nitrogen, and desolventizing was performed, whereby 200.9 g of a solution including 2,5-bisisocyanatomethyl-bicyclo[2.2.1]heptane and 2,6-bisisocyanatomethyl-bicyclo[2.2.1]heptane was obtained. Furthermore, distillation was performed under a reduced pressure, whereby 175.7 g of a mixture of 2,5-bisisocyanatomethyl-bicyclo[2.2.1]heptane and 2,6-bisisocyanatomethyl-bicyclo[2.2.1]heptane having a purity of 99.0% was obtained. The ¹H-NMR chart of the mixture is shown in FIG. 3.

Example 4 Synthesis of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane

After adjusting the catalyst master liquid in the same manner as in Example 1, 0.81 g (0.926 mg in terms of Rh) of the catalyst master liquid and 214.8 g (1.8 mol) of bicyclo[2.2.1]-5-heptene-2-carbonitrile obtained by the method in Reference Example, and 5.656 g (18.23 mmol) of triphenyl phosphite were introduced into an electromagnetic stirring type autoclave made of SUS316L having an internal volume of 0.5 L, and the mixture was stirred at 25° C., whereby 221.3 g of a Rh catalyst adjusting liquid was obtained. When the amount of chlorine atoms in the triphenyl phosphite used at this time was measured by the above analytical method, the result was 160 ppm (0.905 mg). The amount was 1.0 part by weight with respect to 1 part by weight of rhodium.

Amount of rhodium used: 5 ppmmol with respect to 1 mole of bicyclo[2.2.1]-5-heptene-2-carbonitrile

Then, after sufficiently replacing with nitrogen, replacement by a mixed gas having a volume ratio of carbon monoxide/hydrogen of 50/50 was sufficiently performed. The same gas was injected at pressure until the pressure in the autoclave became 0.6 MPaG, and under stirring, the temperature was raised to 80° C., whereby a hydroformylation reaction was started. Since the pressure in the autoclave was reduced with the progress of the reaction, the mixed gas was continuously supplied such that the pressure was maintained at 0. 6 MPaG, the liquid temperature was adjusted so as to be maintained at 80° C., and the time taken for the mixed gas having a volume ratio of carbon monoxide/hydrogen of 50/50 to reach 50% absorption of the theoretical amount was 1.8 hours. The reaction was finished in 5 hours, and the mixed gas in the system was purged with nitrogen, whereby 276.0 g of a reaction liquid including 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed, 258.3 g (1.73 mol) of the compounds was found to be contained therein.

The reaction yield was 96.2 mol %.

The results are shown in Table 1.

Comparative Example 1 Synthesis of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane

In the same manner as in Example 1, the catalyst master liquid was adjusted. Then, 0.81 g (0.926 mg in terms of Rh) of the catalyst master liquid and 214.8 g (1.8 mol) of bicyclo[2.2.1]-5-heptene-2-carbonitrile obtained by the method in Reference Example, and 5.656 g (18.23 mmol) of triphenyl phosphite were introduced into an electromagnetic stirring type autoclave made of SUS316L having an internal volume of 0.5 L, and the mixture was stirred at 25° C., whereby 221.3 g of a Rh catalyst adjusting liquid was obtained. When the amount of chlorine atoms in the triphenyl phosphite used at this time was measured by the above analytical method, the result was 260 ppm (1.471 mg). The amount was 1.6 parts by weight with respect to 1 part by weight of rhodium.

Amount of rhodium used (condition (1)): Rhodium included in rhodium dicarbonylacetylacetonate was 5 ppmmol with respect to 1 mole of bicyclo[2.2.1]-5-heptene-2-carbonitrile

A hydroformylation reaction was performed in the same conditions as in Example 4, and the time taken for the mixed gas having a volume ratio of carbon monoxide/hydrogen of 50/50 to reach 50% absorption of the theoretical amount was 3.2 hours. After the reaction was allowed to proceed for 5 hours, the reaction was stopped, and the mixed gas in the system was purged with nitrogen, whereby 258.4 g of a reaction liquid including 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed, 189.1 g (1.27 mol) of the compounds was found to be contained therein.

The reaction yield was 70.4 mol %.

The results are shown in Table 1.

Comparative Example 2 Synthesis of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane

In the same manner as in Example 1, the catalyst master liquid was adjusted. Then, 0.81 g (0.926 mg in terms of Rh) of the catalyst master liquid and 214.8 g (1.8 mol) of bicyclo[2.2.1]-5-heptene-2-carbonitrile obtained by the method in Reference Example, and 5.656 g (18.23 mmol) of triphenyl phosphite were introduced into an electromagnetic stirring type autoclave made of SUS316L having an internal volume of 0.5 L, and the mixture was stirred at 25° C., whereby 221.3 g of a Rh catalyst adjusting liquid was obtained. When the amount of chlorine atoms in the triphenyl phosphite used at this time was measured by the above analytical method, the result was 370 ppm (2.093 mg). The amount was 2.3 parts by weight with respect to 1 part by weight of rhodium.

Amount of rhodium used: 5 ppmmol with respect to 1 mole of bicyclo[2.2.1]-5-heptene-2-carbonitrile

A hydroformylation reaction was performed in the same conditions as in Example 4, and the time taken for the mixed gas having a volume ratio of carbon monoxide/hydrogen of 50/50 to reach 50% absorption of the theoretical amount was 3.5 hours. After the reaction was allowed to proceed for 5 hours, the reaction was stopped, and the mixed gas in the system was purged with nitrogen, whereby 244.6 g of a reaction liquid including 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed, 173.2 g (1.16 mol) of the compounds was found to be contained therein. The reaction yield was 64.5 mol %.

The results are shown in Table 1.

TABLE 1 Reaction Amount of conditions Yield chlorine Amount Amount Time to after 5 atoms of Rh of TPP reach 50% hours Cl/Rh ratio (ppm (mol/mol- reaction reaction (wt/wt) mol) Rh) (hr) (%) Example 1 0.7 5 2000 1.5 96.0 Example 4 1.0 5 2000 1.8 96.2 Comparative 1.6 5 2000 3.2 70.4 Example 1 Comparative 2.3 5 2000 3.5 64.5 Example 2

In Examples 1 and 4, a hydroformylation reaction smoothly proceeded, and it was possible to achieve a yield equal to or greater than 90% even in the yield after the reaction for 5 hours. In contrast, in Comparative Examples 1 and 2, a hydroformylation reaction slowly proceeded, and also the yield after the reaction for 5 hours was low.

This application claims priority from Japanese Patent Application No. 2012-247499 filed on Nov. 9, 2012, the content of which is incorporated herein by reference in its entirety. 

1. A preparation method of an aldehyde compound, comprising: a step of reacting a compound represented by the following general formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound including 0.01 ppmmol to 10 ppmmol of a metal belonging to Groups 8 to 10 with respect to 1 mole of the compound and a phosphorus compound, wherein the amount of a chlorine portion in the reaction system in the step is equal to or less than 1.5 parts by weight with respect to 1 part by weight of the metal belonging to Groups 8 to 10,

wherein X represents a hydrogen atom, a cyano group, an aldehyde group, or a —CH═NR group, R represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an aryl group, and n represents 0, 1 or
 2. 2. The preparation method of an aldehyde compound according to claim 1, wherein the metal compound including the metal belonging to Groups 8 to 10 is a rhodium compound, a cobalt compound, a ruthenium compound, or an iron compound.
 3. The preparation method of an aldehyde compound according to claim 1, wherein the metal compound including the metal belonging to Groups 8 to 10 is a rhodium compound.
 4. The preparation method of an aldehyde compound according to claim 1, wherein the amount of the metal belonging to Groups 8 to 10 is 1 ppmmol to 5 ppmmol with respect to 1 mole of the compound represented by the general formula (a1) or (a2).
 5. The preparation method of an aldehyde compound according to claim 1, wherein the phosphorus compound is a trivalent phosphorus compound.
 6. The preparation method of an aldehyde compound according to claim 1, wherein the compound represented by the general formula (a1) is used, and the compound is the compound represented by the following formula (1),

wherein X is the same as that in the general formula (a1).
 7. A preparation method of an amine compound comprising a step of reacting the aldehyde compound obtained by the preparation method according to claim 1 with ammonia, and with hydrogen in the presence of a catalyst.
 8. A preparation method of an isocyanate compound comprising a step of reacting the amine compound obtained by the preparation method according to claim 7 with a carbonylating agent. 